98% CNS Drug Failures
BBB Blood-Brain Barrier Models
$35B Neuro Drug Market
FDA 3.0 Human-Relevant NAMs
iPSC Patient-Derived Neurons
MEA Neural Activity Recording
Seizure Liability Testing
Alzheimer's Disease Models
98% CNS Drug Failures
BBB Blood-Brain Barrier Models
$35B Neuro Drug Market
FDA 3.0 Human-Relevant NAMs
iPSC Patient-Derived Neurons
MEA Neural Activity Recording
Seizure Liability Testing
Alzheimer's Disease Models
Blood-Brain Barrier on a Chip

Cross the
Final Frontier.

Human brain-on-chip technology for CNS drug development, neurotoxicity assessment, and neurological disease modeling. Break through the blood-brain barrier bottleneck.

BLOOD-BRAIN BARRIER BLOOD SIDE BRAIN PARENCHYMA MEA ACTIVITY BBB PERMEABILITY PERMEABLE
98%
CNS Drug Trial Failures
$35B
Neuro Drug Market
0.1%
Drugs Cross BBB
100x
Better Than Transwell

Complete Neuroscience Platform

From blood-brain barrier penetration to neural network function, model the entire CNS drug pathway.

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BBB-on-Chip

Human brain microvascular endothelial cells with astrocytes and pericytes forming functional tight junctions.

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Neural Activity

MEA-based electrophysiology recording neural network formation, synchronization, and drug responses.

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Permeability Assays

Quantitative measurement of drug transport across the BBB with efflux transporter characterization.

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Disease Modeling

Patient iPSC-derived neurons recapitulating Alzheimer's, Parkinson's, ALS, and other conditions.

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Seizure Liability

Proconvulsant risk assessment using synchronized neural network activity patterns.

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Target Engagement

Confirm CNS target modulation with functional readouts beyond simple binding assays.

Neurological Disease Models

Patient-derived models for the most challenging neurological conditions.

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Alzheimer's Disease

Amyloid-beta plaques, tau tangles, and neurodegeneration in human cortical neurons

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Parkinson's Disease

Alpha-synuclein aggregation and dopaminergic neuron loss models

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ALS

Motor neuron degeneration with patient-specific SOD1 and C9orf72 mutations

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Epilepsy

Hyperexcitable neural networks for anti-seizure drug screening

Industry Leaders

Organizations advancing brain-on-chip technology for CNS drug discovery.

Emulate BBB-Chip
Brain-Chip with vascular-neural interface and efflux transporters
SynVivo BBB
3D microfluidic BBB models with real-time permeability tracking
Axion BioSystems MEA
Maestro platform for neural activity and seizure liability
Ncardia iPSC
Patient-derived neurons for disease-specific CNS models
MaxWell Biosystems HD-MEA
High-density MEA with 26,000+ electrodes for neural mapping
Mimetas OrganoPlate
Perfused BBB and neural models in high-throughput format

Own the Neuro Platform

NeuroChip.app - the premium domain for brain-on-chip technology and CNS drug development.

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